On the Island of Hven, Tycho Brahe built a Renaissance research center called Uraniborg, “City of the Stars.” The first book printed on Tycho’s printing press at Uraniborg displays his motto, “looking up, I look down.” That motto symbolized his aim of coordinating the study of astronomy, chemistry and medicine in an innovative and collaborative endeavor to discover the secrets of nature. Tycho’s observations of comets and new stars, proving that changes occur in the heavens beyond the Moon, upended the Aristotelian cosmos, paving the way for Galileo’s fundamental astronomical discoveries and advances in physics. In a new world of discovery and innovation, how are we to coordinate the disciplines today? What is nature and how is nature known?