When Galileo announced that “mathematics is the language of nature,” he was making a then-controversial claim about how nature is best known and understood. Mathematics encompassed rich traditions in art and perspective drawing, innovations in musical theory, as well as advances in engineering and mechanics. These discoveries depended upon a rich cultural context that drew science, art, literature and a spirit of creativity together in Renaissance Florence. The Galileo’s World exhibition invites us to participate in a similar Renaissance of discovery at the University of Oklahoma for our 125th anniversary.